Novel 3-(substitutedbenzylideneamino)-5-methyl-1H-pyrazol-1-yl)(phenyl)methanone Derivatives Against Gram-positive, Gram-negative and fungal pathogenic strains

Abstract

          A series of novel3-(substitutedbenzylideneamino)-5-methyl-1H-pyrazol-1-yl)(phenyl) methanone P1-12 derivatives were synthesized. The chemical structures of the compounds were proved by means of their IR, ¹H-NMR, mass spectroscopic data and elemental analyses. The results showed that most of the synthesized compounds exhibited significant anti-bacterial and anti-fungal activities. Among the synthesized compounds P2, P5, P8, and P9 exhibited most potent in vitro antimicrobial activity. On the basis of the microbial results, further  insight  into  the  structural  requirements  for  targeting  pyrazol-1-yl)(phenyl) methanone to develop potential new agents to combat treatment of pathogenic strains.