6-(substitutedbenzylidene)-2-methylthiazolo[2,3-b]oxazol-5(6H)-one Derivatives: New Class of Antihyperglycemic Agent

Abstract

The novel compounds have been prepared in order to improve the pharmacological proï¬les of antihyperglycemic activity. In the present paper, series of 6-(substitutedbenzylidene)-2-methylthiazolo[2,3-b]oxazol-5(6H)-one O1-12 were tested against hyperglycemia. Their antihyperglycemic activity was evaluated by Streptozotocin (STZ) and Sucrose-loaded (SLM) model. The results of studies indicate that, among the compounds O1, O6, O10, O12, O8, and O3 displayed signiï¬cant reduction in blood glucose level in streptozotocin and sucrose loaded rat models. The purity of the synthesized compounds was characterized by means of IR, ¹H-NMR, mass spectral and elemental analysis.