Synthesis and anti-oxidant activity of novel 6,7,8,9 tetra hydro- 5H-5-(2'-hydroxy phenyl)-2-(4'-substituted benzylidine)- 3-(4-nitrophenyl amino) thiazolo quinazoline derivatives

Authors

  • T. Panneer Selvam Department of Biotechnology, Acharya Nagarjuna University, Guntur – 522510, Andrapradesh, India
  • P. Vijayaraj Kumar School of Pharmacy, UCSI (University College Sadaya International) University, Jalan Menara Gading 56000, Cheras, Kuala Lumpur, Malaysia
  • A. Siva Kumar School of Bio Science and Technology, VIT University, Vellore-632014 Tamilnadu, India

Keywords:

Anti-oxidant activity, Benzylidine thiazolo quinazoline, Nitrophenyl amino thiazolo quinazoline, Thiazolo quinazoline

Abstract

In the present study, a series of novel thiazolo quinazoline derivatives were
synthesized by condensation of different aromatic aldehydes with 4-nitro aniline. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, mass spectroscopy and elemental analyses. These compounds were screened for anti-oxidant activity by DPPH radical assay, nitric oxide scavenging activity and Hydrogen Peroxide scavenging activity. Among the synthesized compounds 5d, 5c and 5b was found to be the most potent anti-oxidant activity.

Downloads

Download data is not yet available.

Published

26-12-2010

How to Cite

Selvam, T. P., Kumar, P. V., & Kumar, A. S. (2010). Synthesis and anti-oxidant activity of novel 6,7,8,9 tetra hydro- 5H-5-(2’-hydroxy phenyl)-2-(4’-substituted benzylidine)- 3-(4-nitrophenyl amino) thiazolo quinazoline derivatives. Research in Biotechnology, 1(1). Retrieved from https://updatepublishing.com/journal/index.php/rib/article/view/2329

Issue

Vol. 1 No. 1 (2010)

Section

Research Articles