PEG Conjugated PAMAM Dendrimers with a Anti- HIV Drug Stavudine for prolong release

Authors

  • P. Dinesh Kumar Department of Biotechnology, Acharya Nagarjuna University, Guntur-522510, Andrapradesh, India
  • P.Vijayaraj Kumar School of Pharmacy, UCSI (University ollege Sadaya International) University, JalanMenaraGading 56000 Cheras, Kuala Lumpur, Malaysia
  • T. Panneer Selvam Department of Pharmaceutical Chemistry, PES’s Rajaram and Tarabai Bandekar College of Pharmacy, Faramagudi, Ponda- 403 401, Goa, India
  • K.R.S. Sambasiva Rao Department of Biotechnology, Acharya Nagarjuna University, Guntur-522510, Andrapradesh, India

Keywords:

stavudine, Anti-HIV, PEGylation, Dendrimers, PAMAM

Abstract

The present investigation was aimed to design polyamidoamine (PAMAM) dendrimer having polyethylene glycol grafts as novel drug carrier. In this study we successfully synthesized and conjugated PEGylated PAMAM dendrimers with anti HIV drug stavudine. Hemolytic toxicity studies were carried out for PEGylated PAMAM dendrimers which showed that haemolysis of cell was very negligible in PEGylated PAMAM dendrimers. Moreover surface were characterization of PEGylated PAMAM dendrimers was carried out TEM micrographs. Further physiochemical and physiological parameter such as UV, DSC, drug entrapment and drug release were carried out for PEGylated and non PEGylated PAMAM dendrimers. Drug loading, drug release and toxicity are better for PEGylated PAMAM dendrimers.

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Published

21-03-2013

How to Cite

Kumar, P. D., Kumar, P., Selvam, T. P., & Rao, K. S. (2013). PEG Conjugated PAMAM Dendrimers with a Anti- HIV Drug Stavudine for prolong release. Research in Biotechnology, 4(2). Retrieved from https://updatepublishing.com/journal/index.php/rib/article/view/2425

Issue

Vol. 4 No. 2 (2013)

Section

Research Articles