Antioxidant and anti-proliferative potential of Cardiospermum halicacabum stem extracts against human breast cancer (MCF-7) cells
DOI:
https://doi.org/10.25081/cb.2022.v13.7615Keywords:
C. halicacabum, Phytochemical Analysis, Antioxidant, Antiproliferative DPPH, MCF-7, MTTAbstract
Cancer is the most important health care problem worldwide. An estimated 10 million new cases worldwide are recorded annually, of which 46% are in developed countries. Breast cancer is one of the second most common malignant tumors in the world. All forms of cancer treatment, including surgical treatment, chemotherapy and/or radiotherapy are often poor and often toxic to the normal cell. Therefore, there is still an urgent need for new cancer treatment options. More research is now being done to determine which compounds occur naturally. The current study aims to extract Cardiospermum halicacabum L. for the prevention and treatment of cancer. A few methods may account for the perceived therapeutic effects, most importantly direct cytotoxicity. These herbal medicines when combined with regular antioxidant and anticancer drugs may be helpful in combining the antioxidant and anticancer effects and reducing the side effects associated with common drugs.
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Abu-Rabia, A. (2005). Urinary diseases and ethnobotany among pastoral nomads in the Middle East. Journal of Ethnobiology and Ethnomedicine, 1, 4. https://doi.org/10.1186/1746-4269-1-4
Ahmed, I., Ahmed, M., & Ahmed, A. (1993). Chemical investigation of the genus Cardiospermum of the family sapindaceae. Science International Lahore, 5, 67-69.
Alagesaboopathi, C. (2011). Ethnomedicinal plants used as medicine by the Kurumba tribals in Pennagaram region, Dharmapuri district of Tamilnadu, India. Asian Journal of Experimental Biological Science, 2, 140-142.
Angalammal, P., AlSalhi, M. S., Sivakumari, K., Devanesan, S., Rajesh, S., & Tamizhazhagan, V. (2021). Phytochemical evaluation and anticancer activity of rambutan (Nephelium lappaceum) fruit endocarp extracts against human hepatocellular carcinoma (HepG-2) cells. Saudi Journal of Biological Sciences, 28 (3), 1816-1825. https://doi.org/10.1016/j.sjbs.2020.12.027
Boopathi, C. A., & Sivakumar, R., (2011). Phytochemical screening studies on the leaves and stem of Andrographis neesiana wight – An endemic medicinal plant from India. World Applied Science Journal, 12, 307-311.
Chau., G. Y, Lui, W. Y., Tsay, S. H., Chao, Y., King, K. L., & Wu, C. W. (2006). Post-resectional adjuvant intraportal chemotherapy in patients with hepatocellular carcinoma. A case-control study, Annals of Surgical Oncology, 13(10), 1329-1337. https://doi.org/10.1245/s10434-006-9004-1
Dwarakan, P., & Alagesaboopathi, C. (1999). Traditional crude drug resources used for human and live-stock diseases in Salem district, Tamilnadu. Journal of Economic and Taxonomic Botany, 23, 421-424.
Ferrara, L., Schettino, O., & Montesano, D. (1996). Triterpenoids from Cardiospermum halicacabum L. Phytotherapy Research, 10, S192-S194.
Hemalatha, G., Sivakumari, K., Rajesh, S., & Shyamala Devi, K. (2020). Phytochemical profiling, anticancer and apoptotic activity of Graviola (Annona muricata) fruit extract against human hepatocellular carcinoma (HepG-2) cells. International Journal of Zoological Applied Bioscience, 5(1), 32-47. https://doi.org/10.5281/zenodo.3735733
Hersh, E. M., & Freiriech, E. J. (1968). In H. Bush, (Eds.), Methods in Cancer Research (Vol. 4, pp. 355A) New York, USA: Academic press.
Kokate, C. K., (1988). Tannins. In C. K. Kokate, (Eds.), Pharmocognosy (24th ed., pp.184) Pune, India: Nirali Prakashan.
Manimekalai, I., Sivakumari, K., Ashok, K., & Rajesh, S., (2016). Antioxidant and anticancer potential of mangosteen fruit, Garcinia mangostana against hepatocellular carcinoma (HepG-2) cell line. World Journal of Pharmacy and Pharmaceutical Sciences, 5(2), 253-293.
Misra, A. (2009). Studies on biochemical and physiological aspects in relations to phytomedicinal qualities and efficacy of the active ingredients during the handling, cultivation and harvesting of the medicinal plants. Journal of Medicinal Plants Research, 3(13), 1140-1146.
Mohamad Sitheek, A., Sivakumari, K., Rajesh, S., & Ashok, K., (2020). Anti-proliferative effect of durian fruit (Durio zibethinus) against HL-60 cells and its phytochemical analysis. Journal Advance Science Research, 11(S5), 174-181.
Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65(1-2), 55-63. https://doi.org/10.1016/0022-1759(83)90303-4
Ncube, N. S., Afolayan, A. J., & Okoh, A. I., (2008). Assessment techniques of antimicrobial properties of natural compounds of plant origin: Current methods and future trends. African Journal of Biotechnology, 7(12), 1797-1806. https://doi.org/10.4314/ajb.v7i12.58804
Padmavathy, K., Sivakumari, K., Karthika, S., Rajesh, S., & Ashok, K., (2021). Phytochemical profiling and anticancer activity of dragon fruit Hylocereus undatus extracts against human hepatocellular carcinoma cancer (HepG-2) cells. International Journal of Pharmaceutical Sciences and Research, 12(5), 2770-2778. https://doi.org/10.13040/IJPSR.0975-8232.12(5).2770-78
Rajesh, S., & Sivakumari K. (2020). Anticancer Activity of Isolated Fractions from Cardiospermum halicacabum Methanol Leaf Extract on Human Hepatocellular Carcinoma (HepG-2) Cells. Indian Journal of Natural Sciences, 10(62), 28286-28293.
Rajesh, S., Sivakumari, K., & Ashok, K. (2020). Antioxidant potential of isolated fractions from methanol leaf extract of Cardiospermum halicacabum. Journal of Advanced Scientific Research, 11(S5), 13-16.
Rajesh, S., Sivakumari, K., & Ashok, K. (2016a). In Silico Docking of Selected Compound from Cardiospermum halicacabum Linn. Leaf against Human Hepatocellular Carcinoma (HepG-2) Cell line. International Journal of Computational Bioinformatics and In Silico Modeling, 5(2), 780-786.
Rajesh, S., Sivakumari, K., Ashok, K., & Abitha, A. R. (2016b). Anti-cancer activity of Cardiospermum halicacabum Linn. Leaf extracts against hepatocellular carcinoma cell line (HepG-2). World Journal of Pharmacy and Pharmaceutical Sciences, 5(3), 1133-1154.
Rajesh, S., Sivakumari, K., Ashok, K., & Abitha, A. R. (2016c). Anti-cancer activity of Cardiospermum halicacabum Linn. Leaf extracts against human breast cancer cell line (MCF-7). European Journal of Biomedical and Pharmaceutical Sciences, 3(10), 213-222.
Savithramma, N., Rao, L. M., & Ankanna, S. (2011). Screening of traditional medicinal plant for secondary metabolites. Middle-East Journal of Science Research, 8, 579-584.
Savithramma, N., Venkateswarlu, P., Suhrulatha, D., Basha, S. K. M., & Venkataramanadevi C. H. (2010). Studies of Boswellia ovalifoliolata Bal. and Henry - An endemic and endangered medicinal plant. The Bioscience, 5, 359-362.
Srinivas, K., Choudary, K. A., & Rao, S. S. (1998). Phytochemical examination of Cardiospermum halicacabum Linn. Indian Journal of Natural Product, 14, 24-27.
Vinoth, S., Rajesh Kanna, P., Gurusaravanan, P., & Jayabalan, N. (2011). Evaluation of phytochemical, anti-microbial and GC-MS analysis of extracts of Indigofera trita L.F.spp. subulata (Vahl ex poir). International Journal Agricultural Research, 6(4), 358-367. https://doi.org/10.3923/ijar.2011.358.367
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