Effect of aflatoxin B1 on DNA structural characteristic

Abstract

The present investigation is an attempt to detection the effect of aflatoxin B1 on structural characteristic of DNA in different tissue, include liver, kidney, spleen and blood, in vivo by treated weight albino rate to AFB1 for 2 weeks as oral daily dose 1 ml/ kg. DNA fragmentation test was used to detect changes in DNA and micronuclei test in bone marrow cell. the results show that AFB1 causes lyses in DNA in all tissue and blood in variant level compare with negative control, liver show greater level than other organs 9660 pb, spleen was 9133 pb, kidney was 6166 pb and lower level in blood was 1366 pb. So it cause increased in micronuclei formation in bone marrow cell.