Antimitotic Effect of Ethanol Fraction of Hibiscus mutabilis Leaf and Flowers

Abstract

Hibiscus mutabilis is reported for bioactive constituent. Ethanol fraction of Hibiscus mutabilis leaf and flower were studied for antimitotic activity. Allium cepa roots were used to evaluate cytotoxicity effect of the extracts. Ethanol soluble part of leaf and flower showed inhibitory effect on root length and root number growth on third day of incubation which is comparable with paracetamol as standard drug used. Reduction in number of dividing cells in the root meristem due to ethanolic fraction of leaf reveals antimitotic activity which is dose dependant. The constituents present in ethanolic extract may be responsible for cytoskeleton or tubulin polymerization or degradation that demonstrates antimitotic behavior.