Acetylcholinesterase inhibition and phyto-constituents


  • Munish Kumar Navneet Kaur Randhava2, 4, Sweety Devi


Plants are the next door neighbors for the people from ancient time, which are used to fulfill daily needs. Most of the population still uses the traditional medicines to cure disease by following their indigenous protocols. Acetylcholine (Ach) is a neurotransmitter, helps in boosting memory and learning. Disturbance in Ach production and release causes fatal disease like Alzheimer and neuro-muscular disorders. Donepezil, Galantamine and other Acetylcholinesterase inhibitor are used to treat them. These drugs prevents rapid hydrolysis of Acetylcholine by antagonize the action of Acetylcholinesterase. Now a day’s most of the research is being carried on natural source. Numerous phyto- constituents are under clinical trial to validate its potential scientifically. Plants and phyto- chemicals are assessed to potentiate the acetylcholine production and delay its hydrolysis. This communication is only to provide the list of plants and their phyto- constituents which antagonize the Acetylcholinesterase action. It consists of plant and their Phyto- constituents which are tested in last 7 years with IC50 value.


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How to Cite

Navneet Kaur Randhava2, 4, Sweety Devi, M. K. “Acetylcholinesterase Inhibition and Phyto-Constituents”. Research in Pharmacy, vol. 4, no. 4, Oct. 2015,