Protective effect of bischalcone derivative in Drosophila melanogaster against electron beam radiation

Abstract

In this paper the protective effect of (2E, 5E) – 2,5-bis (3-methoxy-4-hydroxybenzylidene) cyclopentanone bischalcone derivative (Curcumin analogue, CA), on electron beam radiation induced oxidative stress in Drosophila melanogaster adult flies. Curcumin (CU) was taken as standard. The CA pre treated and irradiated flies were screened for wing shape abnormalities in F1 and F2 generations. There was considerable decrease in the wing shape abnormality frequency in the case of CA fed irradiated flies compared to control.