Design and evaluation of timolol maleate ocuserts

Abstract

A remarkable attempt was made to prepare timolol maleate ocuserts, which is significant beta adreno receptor antagonist, by the aid of different of different ratio of composition of polymers such as EC, HPMC and Eudragit RS 100. Twelve batches of suitable ophthalmic films formulated by the method of solvent casting technique. Out of which the best formulation was found out the zero order release was observed in batch and was considered as the least drug releasing one. The formulated ocuserts were flexible, uniform and was meant for physic-chemical evaluator parameters, in vitro drug release profile and in vivo evaluation made on male rabbit.