Effect of polymeric activity on transdermal patches of Glipizide

Abstract

An effort was made to formulate transdermal patches of Glipizide which is a potent antidiabetic drug by using different ratio of polymers like hydroxy propyl methyl cellulose, ethyl cellulose and Eudragit. Eight batches of transdermal patches were prepared by solvent casting technique in which the best formulation was found out. The polymers such as HPMC, Ethyl cellulose, Eudragit were incorporated with Glipizide in various proportions, out of which the best formulation on the ratio (HPMC: EC: Eudragit - 2:2:1) with the drug was determined. The prepared transdermal patches were uniform in shape and white in color which was calculated for physicochemical characteristics, invitro release profile, and in-vivo evaluation on mice. Higuchis plot studies revealed that the predominant mechanism of drug release was diffusion.