Development and Comparative Antibacterial Evaluation of Tincture of Jatropha gossypifolia L. Leaves

Abstract

Objective: To compare antibacterial activity of tincture of Jatropha gossypifolia L., leaves against marketed tincture.

Methods: The tincture was formulated using methanolic extract of J. gossypifolia leaves. It was evaluated for its density, dry matter, pH, refractive index and content of methanol using appropriate formulae. Further, the tincture of J. gossypifolia leaves was compared with marketed tincture, Povidone Iodine for antibacterial activity using agar well diffusion method against strains such as E.coli, E.faecalis, B.subtilis and S.aureus.

Results: The results observed from the study complies prerequisites of a tincture and showed comparative antibacterial activity with that of marketed tincture, Povidone Iodine.

Conclusion: J. gossypifolia leaves have different pharmacological activities. The comparative evaluation of formulated tincture against marketed tincture showed significant antibacterial activity. Further, this study suggests isolating, identifying and evaluating the phytochemical substances and related pharmacological activity.