Research studies on polymeric effect of indomethacine transdermal films

Abstract

The objective of this study was to design and evaluate transdermal patches of Indomethacine using HPMC, EC and Eudragit RLPO using solvent casting technique. The in vitro drug release studies were performed by using the USP (paddle type) dissolution list apparatus in 1000 ml of 0.1N HCl (Medium Employed) at 37o C room temperature for an rpm maintained at 100 within a stipulated time interval of 15 minutes. The withdrawn Samples were analyzed by using UV visible  spectrophotometer at 268 mm using regent blank. The prepared  transdermal patches had undergone physic chemical evaluator parameters such as PMA, PML, swelling index, water vapour transmission rate, film thickness, weight cheek, and folding Endurance and drug content clearance. In vitro dissolution study of drug along with different  combination of polymers; i.e. HPMC, EC and Eudragit has been  performed; out of which batch B6 shows the best moisture of films and the graph representing the best controlled drug release. As the percentage of ethyl cellulose was reduced the rate of the release of the drug was increased. [Batch B6 > HPMC: EC: Eudragit RLPO - 2:1:2]. Films with batch  code B6 shows better stability and suitability. Higuchi’s plot revealed that the predominant Mechanism of drug release was diffusion