Formulation and evaluation of controlled release matrix tablets of antihypertensive drug using natural and synthetic hydrophilic polymers

Authors

  • Mohd Azharuddin Dept. of Pharmacy, Srinivas College of Pharmacy, Valachil, Mangalore- 574 143, Karnataka
  • Krishnananda Kamath Dept. of Pharmacy, Srinivas College of Pharmacy, Valachil, Mangalore- 574 143, Karnataka
  • T. Panneerselvam Dept. of Pharmacy, Srinivas College of Pharmacy, Valachil, Mangalore- 574 143, Karnataka
  • Subash S. Pillai Dept. of Pharmacy, Srinivas College of Pharmacy, Valachil, Mangalore- 574 143, Karnataka
  • A.R. Shabaraya Dept. of Pharmacy, Srinivas College of Pharmacy, Valachil, Mangalore- 574 143, Karnataka

Keywords:

Losartan potassium, Natural gum, Synthetic polymer, Controlled release

Abstract

The present study is to prepare and evaluate controlled release matrix tablets of Losartan potassium using natural and synthetic polymers. Tablets were prepared by direct compression method using different drug: polymer concentration. Fourier Transform Infrared Spectroscopy (FT-IR) and Differential Scanning Calorimetry (DSC) study revealed no chemical interaction between drug and polymers used. Precompression and postcompression parameters complied with pharmacopoeial limit for the tablets. In-vitro release studies was performed and the results indicates that matrix tablet  (F9) containing 50% w/w blend of natural and synthetic polymer has better controlled release for a period of 24 h.

Downloads

Download data is not yet available.

Published

23-09-2011

How to Cite

Azharuddin, M., Kamath, K., Panneerselvam, T., S. Pillai, S., & Shabaraya, A. (2011). Formulation and evaluation of controlled release matrix tablets of antihypertensive drug using natural and synthetic hydrophilic polymers. Research in Biotechnology, 2(4). Retrieved from https://updatepublishing.com/journal/index.php/rib/article/view/2366

Issue

Vol. 2 No. 4 (2011)

Section

Research Articles

Most read articles by the same author(s)