Regulation of cell proliferation and tumor suppressor roles of microRNA 329-3p of the MAP kinase pathway in cervical squamous carcinoma

Authors

  • Elfansu Division of Molecular Biology, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru-570015, Karnataka, India
  • Faria Rashid Tenby International School Ipoh, Malaysia
  • K. Abirami Department of Microbiology, Vivekanandha College of Arts and Science for Women, Tiruchengode, Namakkal- 637205, Tamil Nadu, India
  • Sivakumar Krishnamoorthy Agricultural Microbiology, Institute of Horticulture, Horticulture Research Station, Tamil Nadu Agriculture University, Pechiparai, Kanyakumari-629161, Tamil Nadu, India
  • Kshitija Aherkar Division of Molecular Biology, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru-570015, Karnataka, India
  • R. Mythreyi Division of Molecular Biology, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru-570015, Karnataka, India
  • Uthamalingam Murali Department of Surgery, Manipal University College Malaysia, Malaysia
  • Kanthesh M. Basalingappa Division of Molecular Biology, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru-570015, Karnataka, India
  • Selvaraj Jagannathan Department of Microbiology, Pasteur Institute of India, Coonoor, The Nilgiris-643103, Tamil Nadu, India
  • E. Boojhana Department of Microbiology, Muthayammal College of Arts and Science, Rasipuram, Namakkal-637408, Tamil Nadu, India
  • M. Maghimaa Department of Microbiology, Muthayammal College of Arts and Science, Rasipuram, Namakkal-637408, Tamil Nadu, India

DOI:

https://doi.org/10.25081/rrst.2024.16.8922

Keywords:

Cervical cancer, Squamous cell carcinoma, Biomarker, Proliferation, Metastasis, Apoptosis

Abstract

Cervical squamous cell carcinoma is observed as the second major cause of mortality worldwide. A highly conserved mitogen-activated protein kinase (MAPK) signaling pathway occurs in a wide range of cellular processes which includes differentiation, proliferation, migration, senescence, and apoptosis. MAPK pathway can be activated by various extracellular signals, capable of generating responses as per the cell type. Thus, alteration of the EGFR receptor in this particular pathway leads to the condition of cancer due to abnormal activation of receptor tyrosine kinases. The characteristic features of microRNA (miRNA) which are endogenous, single-stranded, small non-coding RNA for their role in RNA silencing and post-transitional regulation of gene expression have been studied over the years. The miRNA functions by base pairing with the complementary sequences within the mRNA molecule. One such miRNA, miR-329-3p has a critical tumor suppressor role in the MAPK pathway, however, is least understood. Therefore, miRNA could be considered as a potential biomarker for diagnosis, prognosis, and therapeutic purposes and brought out to its fullest use to mankind.

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Published

04-06-2024

How to Cite

Elfansu, Rashid, F., Abirami, K., Krishnamoorthy, S., Aherkar, K., Mythreyi, R., Murali, U., Basalingappa, K. M., Jagannathan, S., Boojhana, E., & Maghimaa, M. (2024). Regulation of cell proliferation and tumor suppressor roles of microRNA 329-3p of the MAP kinase pathway in cervical squamous carcinoma. Recent Research in Science and Technology, 16, 8–14. https://doi.org/10.25081/rrst.2024.16.8922

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Volume 16, 2024

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