UMH.48 (NCBI JN807465) the Fungus causing Rhinosporidiosis is sensitive to anti fungal

Abstract

UMH.48, JN807465, a fungus causing Rhinosporidiosis was isolated in pure culture from biopsies from patients with nasal Rhinosporidiosis. It was  identified as a lower aquatic fungus by 18S rRNA gene sequencing which compared 100% similar to the sequences from fungal extract of the tissue, thus establishing the etiologic role of UMH.48 in Rhinosporidiosis. UMH.48 18S rRNA sequence showed significant similarity with Synchytridium minutum and very low varying percentages of similarity with Mycobacterium sps., Corynebactrium sps., and Actinomycetales. The organism was tested for susceptibility and sensitivity to antibiotics and antifungal drugs such as  Norfloxacin, Dapsone, Rifampicin and Amphotericin B. UMH.48 was highly sensitive to Amphotericin B and Rifampicin. It was resistant to Dapsone at the concentrations tested.