Molecular analysis of Candidate genes at the 22q region in Schizophrenia subjects

Authors

  • Kiran Kumar Halagur Bhoge Gowda National Centre for Biological Sciences, Bangalore-29, India
  • Jay Rao Dept. of Psychiatry, London Health Sciences Centre, London, Ontario, Canada N6A 5B7
  • Richard O'Reilly Dept. of Psychiatry and London Health Sciences Centre, London, Ontario, Canada N6A 5B7
  • Shiva M. Singh Molecular Genetics Unit, Department of Biology, University of Western Ontario Dept. of Psychiatry, London, Ontario, Canada N6A 5B7

Keywords:

Velo-Cardio-Facial Syndrome (VCFS), 22q deletion syndrome, Schizophrenia(SCZ), Copy number variations(CNV)

Abstract

22q11.2 deletion syndrome (22q11.2DS), also known as Velo-Cardio-Facial Syndrome (VCFS) or DiGeorge Syndrome, is a genetic disorder due to a micro deletion on chromosome 22q11.2. VCFS is associated with abnormalities in brain structure and with an increased risk of psychiatric disorders, particularly schizophrenia (SCZ). DNA copy  number is a largely unexplored source of human genetic variation that may contribute risk for complex disease like SCZ. The aim of this study was to assess Copy number variations (CNV) at candidate genes located in 22q11 region in SCZ subjects. We report aberrations in copy number  at PRODH and COMT gene loci supporting the hypothesis that dosage effects of 22q genes could lead to disruptions in neurotransmitter signaling and related neurobehavioral symptoms observed in SCZ subjects. The results support the hypothesis that the complex phenotype of 22qDS results either from the overlapping regulation of several genes within this region or from its concerted participation in a highly regulated process.

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Published

13-12-2012

How to Cite

Bhoge Gowda, K. K. H., Rao, J., O’Reilly, R., & Singh, S. M. (2012). Molecular analysis of Candidate genes at the 22q region in Schizophrenia subjects. Research in Biotechnology, 3(6). Retrieved from https://updatepublishing.com/journal/index.php/rib/article/view/2344

Issue

Vol. 3 No. 6 (2012)

Section

Research Articles