Effect of Vinca minor on biochemical parameters using Wistar albino rats
DOI:
https://doi.org/10.25081/jsa.2019.v3.5487Keywords:
Vinca minor, haematology, liver enzymes, kidney function.Abstract
Effect of Vinca minor on biochemical parameters using Wistar albino rats was investigated to ascertain the plant`s haematotoxicity, liver and kindey tissue damage potential. Haematological indices and markers of liver and kidney for cellular integrity were monitored in rats given different concentrations of leaf extract of V.minor. Results obtained showed significant reduction (p<0.05) in PCV and Hb of test rats against the control. Test rats also had significant increase (p<0.05) in liver enzymes and marked significant (p<0.05) reduction in urea and some electrolytes in test rats when compared to control. The loss of integrity of the liver cells, retention of the urea and some electrolytes in the kidney would certainly lead to a possible disease condition with time. This study has shown the effect of V.minor on biochemical parameters using Wistar albino rats.
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[31]. Duru M, Amadi B, Njoku V. Evaluation of some chemical constituents of “ji-otor” and “ntubiri ikpa” traditional foods of Ikwerre ethnic national in Nigeria. Proceedings of the 36th Annual International Conference, Workshop & Exhibition of Chemical Society of Nigeria.2013; Vol.1.pp 38-44.
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[35]. Amadi BA, Duru MKC, Eze AA, Amadi CT. (2013).Sensory evaluation, mineral, and amino acid composition of “ntubiri” and “ntiti-ikpa”, traditional foods of Ikwerre ethnic nationality in Nigeria. Pacific Journal of Science and Technology.2013; 14(1):295-300.
[36]. Ugbogu AE, Okezie E, Uche-Ikonne C, Duru M, Atasie OC. Toxicity evaluation of the aqueous stem extracts of Senna alata in Wistar rats. American Journal of Biomedical Research. 2016; 4(4): 80-86.
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[41]. Adebayo AH, Abolaji AO, Opata TK, Adegbenro IK. Effects of ethanolic leaf extract of Chrysophyllum albidum G. on biochemical and haematological parameters of albino Wistar rats. African Journal of Biotechnology.2010; 9 (14): 2145– 2150.
[42]. Duru MKC, Amadi BA, Amadi CT, Lele KC, Anudike ,JC, Chima-Ezika OR, Osuocha K. Toxic effect of carica papaya bark on body weight, haematology, and some biochemical parameters. Biokemistri. 2012; 24(2):67-71.
[43]. Amadi BA, Agomuo EN, Duru MKC. Toxicological studies of Asmina triloba leaves on haematology, liver, kidney using rat model. International Science Research Journal. 2013; 4(2):11-17.
[44] Celik I, Suzek H. The hematological effects of methyl parathion in rats.Journal of Hazardous Materials.2008; 153 (3): 1117–1121.
[45] Adebayo, JO, Adesokan AA, Olatunji, LA, Buoro DA, Soladoye AO. Effect of ethanolic extract of Bougainvillea spectabilis leaves on haematological and serum lipid variables in ratsitm. Biokemistri. 2005; 17 (1): 45–50.
[46]. Hassan DI, Ogah, DM, Yusuf ND, Musa MM, Saidu GM. The effect of acute and chronic (short and long term) oral administrations of black pepper (Piper guineense) aqueous extract on the body weight and haematological values of albino- Wistar rat. Journal of Medicinal Plants Research. 2010; 4 (2):1122–1125.
[47]. Akubugwo EI, Duru MKC. Biochemical Implications of the consumption of water from Otamiri river, Owerri, Imo State, Nigeria. Journal of Emerging Trends in Engineering and Applied Sciences (JETEAS).2011; 2 (6): 934-937.
[48]. Olson H, Betton G, Robinson D, Thomas K, Monro A, Kolaja G, Lilly P, Sander J, Spies G, Bracken W, Dorato M, Deun KV, Smith P, Berger B, Heller A. Concordance of toxicity of pharmaceuticals in humans and in animals. Regul. Toxicol. Pharmacol. 2000; 32:56-67.
[49]. Duru MKC, Adindu EA, Odika PC, Amadi BA, Okazi CR. Consequences of long-term consumption of water from Nworie River (Owerri, Nigeria) on haematological, hepatic, and renal functions using rat model. Biokemistri.2012; 24 (1):52-57.
[50]. Aliyu R, Adebayo AH, Gatsing D, Garba IH. The effect of ethanolic leaf extract of Commiphora africana (Burseraceae) on rat liver and kidney functions. J. Pharmacol. Toxicol.2006; 2: 373-379.
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[3]. Adebayo AH, Abolaji AO, Opata TK, Adegbenro IK. Effects of ethanolic leaf extract of Chrysophyllum albidum G. on biochemical and haematological parameters of albino Wister rats. African Journal of Biotechnology.2010; 9(14): 2145-2150.
[4]. Nwachukwu MI, Duru MKC, Nwachukwu IO, Obasi CC, Uzoechi AU, Ezenwa CM, Anumodu CK. In-vitro phytochemical characterization and antibacterial activity of Newbouldia laevis (boundary tree) on Escherichia coli and Staphylococcus aureus. Asian Journal of Microbiology and Biotechnology.2017; 2(1): 30-36/ [5]. Nawrot P, Jordan S, Eastwood J, Rotstein J, Hugenholtz A, Feeley M. Effects of caffeine on human health. Food Additives and Contaminants. 2003; 20 (1): 1–30.
[6]. Agomuo EN, Amadi BA, Duru MKC. Some biochemical studies on the leaves and fruits of Persea americana. International Journal of Research and Reviews in Applied Sciences. 2011; 11(3):565-569. [7]. Agomuo EN, Duru MKC, Amadi BA. Some bioactive constituents of Asmina triloba (paw paw) leaf variety. International Science Research Journal. 2013; 4(2):18-22.
[8]. Agomuo E, Duru M, Amadi B, Amadi P, Ugwokaegbe P. Effect of caffeine on some selected biochemical parameters using rat model. Advances in Biology. 2017, Article ID 9303276, 8 pages. https://doi.org/10.1155/2017/9303276
[9]. Sofowara A. Medicinal plants and traditional medicine in African. Spectrum Books Ltd, Ibadan, Nigeria, 1993, pp. 191-289.
[10]. Duru MKC., Arukwe U, Amadi, BA. (2011): Bioactive constituents and macronutrients composition of anti-malarial concoction used in Umunchi village in Isiala Mbano L.G.A of Imo State, Nigeria. International Science Research Journal. 2011;3:61-64.
[11]. Duru M, Amadi B, Ugbogu A, Eze A. Effect of “udu”, an antimalarial herbal preparation on visceral organ weight and blood lipid profiles in wistar rats. International Journal of Research and Reviews in Applied Sciences. 2014; 11(3):1-7.
[12]. Gill LS. Ethnomedical uses of plants in Nigeria.University of Benin Press, Nigeria, 1992; pp.215. [13]. Ayitey-Smith E. Prospects and Scope; Plant Medicine in Healthcare.Ghana Univ. Press, 1989; pp. 29. [14]. Duru MKC, Amadi BA, Eze AE, Ugbogu AE, Onuoha N. In vivo studies of Solanum aethiopicum fruit on some biochemical parameters using rats. Journal of Chemical and Pharmaceutical Research. 2013; 5(2):1-4. [15]. Duru MKC, Agomuo EN, Amadi BA. Biochemical studies on “udu” an antimalarial concoction used in Umunchi village, Isiala Mbano L.G.A of Imo State, Nigeria. Continental Journal of. Pharmacology and Toxicology Research.2012; 5 (2): 28 – 34. `
[16]. Nwachukwu, MI, Duru, MKC, Amadi BA, Nwachukwu IO. Comparative evaluation of phytoconstituents, antibacterial activities and proximate contents of fresh, oven dried uncooked and cooked samples of Buchholzia coriacea seed and their effects on hepatocellular integrity. International Journal of Pharmaceutical Science Invention.2014 3(6):41-49.
[17]. Duru MKC, Arukwe U, Amadi BA. Bioactive constituents and macronutrients composition of anti-malarial concoction used in Umunchi village in Isiala Mbano L.G.A of Imo State, Nigeria. International Science Research Journal. 2011; 3: 61 – 64.
[18]. Farahanikiaa B, Akbarzadehb T, Jahangirzadeha A, Yassaa N, Ardekania MRS, Mirnezamia T, Hadjiakhoondia A, Khanavia M. Phytochemical Investigation of Vinca minor Cultivated in Iran. Serv. Iran. J. of Pharm. Res. 2011; 10: 777-785.
[19]. Kurt S, Carol K. Impact and control of Vinca minor L. in an Illinois forest preserve (USA). Nat. Areas J. 2000; 20: 189-196.
[20]. Sara A, Ulrike B, Frank S, Fatma M, Abdel B, Mohamed MA, Farid AB, Mahdi Y, Mark B, Dirk S. Treatment of Vinca minor leaves with Methyl Jasmonate extensively alters the pattern and composition of indole alkaloids. J. Nat. Prod., 2017, 80 (11), pp 2905–2909.
[21]. Devi B, Bhattacharya S. Influence of amf (Glomus coronatum and Glomus etunicatum) on plant growth and physiological parameters of Vinca minor growing under himalayan condition. World Journal of Pharmaceutical Research 7(3): 1686-1712.
[22]. Amadi B, Onuoha N, Amadi C, Ugbogu A, Duru M. Elemental, amino acid and phytochemical constituents of fruits of three different species of eggplants. International Journal of Medicinal and Aromatic Plants. 2013; 3(2):200-203.
[23]. Duru M, Eboagwu I, Kalu W, Odika P. Nutritional, Anti-nutritional and Biochemical Studies on the Oyster Mushroom, Pleurotus ostreatus. EC Nutrition.2019; 14 (1): 36-59.
[24]. Duru M, Nwadike C, Ezekwe A, Nwaogwugwu C, Eboagwu I, Odika P, Njoku S, Chukwudoruo C. Evaluation of nutritional, anti-nutritional and some biochemical studies on Pleurotus squarrosulus (Mont.) singer using rats. African Journal of Biochemistry Research. 2018;12 (2):7-27.
[25]. Amadi B, Duru M, Agomuo E, Amadi P, Onedibe O. Nutritional, phytochemical and sensory evaluation of “Mberiagworagwo” traditional food of Uruagunnewi people in Anambra State, Nigeria. Journal of Advances in Biology & Biotechnology.2017;14(1): 1-8.
[26]. Amadi BA, Arukwe U, Duru MKC, Adindu EA, Ufornwa EC, Odika PC. The effect of fermentation on anti-nutrients, carbohydrates and vitamin contents of Pentaclethra macrophylla seed. International Science Research Journal. 2011; 3: 74 – 77.
[27]. Duru M, Amadi C, Ugbogu A, Eze A, Amadi B. Phytochemical, vitamin and proximate composition of Dacryodes edulis fruit at different stages of maturation. Asian Journal of Plant Science and Research. 2012; 2 (4):437-441.
[28]. Duru M, Agomuo E, Amadi B, Iheanacho A, Nutritional evaluation and some biochemical studies on Ageratum conyzoides using its different parts. Proceedings of the 35th Annual International Conference, Workshop & Exhibition of Chemical Society of Nigeria. 2012; Vol. 1. pp 372-379.
[29]. Duru M, Ugbogu A, Amadi B, Odika P, Chima-Ezika R, Anudike J, Osuocha K. Chemical constituents of Buchholzia coriacea seed. Proceedings of the 35th Annual International Conference, Workshop & Exhibition of Chemical Society of Nigeria.2012; Vol. 2. pp. 39-45. [30]. Duru MKC, Amadi BA, Agomuo EN, and Njoku VO. The effect of fresh, oven dried uncooked and cooked seeds of Buchholza coriacea on weight of visceral organs, tissue lipid and testosterone. Proceedings of the 37th Annual International Conference, Workshop & Exhibition of Chemical Society of Nigeria.2014; pp 127-132.
[31]. Duru M, Amadi B, Njoku V. Evaluation of some chemical constituents of “ji-otor” and “ntubiri ikpa” traditional foods of Ikwerre ethnic national in Nigeria. Proceedings of the 36th Annual International Conference, Workshop & Exhibition of Chemical Society of Nigeria.2013; Vol.1.pp 38-44.
[32]. Duru M, Amadi B, Eze A, Ugbogu A. Evaluation of “mgbam” traditional food on haematological profile and some selected biochemical parameters following consumption. Elixir Food Science. 2013; 64: 19345-19349. [33]. Duru M, Amadi B, Ugbogu A, Onuoha N. Effect of “Nduduagworagwo” traditional food on haematology, hepatic and renal function of rats. Asian Journal of Agriculture and Food Science. 2013; 1 (1):21-27. [34]. Amadi BA, Duru MKC, Nwachukwu MI. Nutritional and anti-nutritional evaluation of “Ji-otor” and “Ntubiri-ikpa” traditional foods of ikwerre ethnic national in Nigeria. Journal of Chemical, Biological and Physical Sciences, 2013; 3 (3): 1953-1962.
[35]. Amadi BA, Duru MKC, Eze AA, Amadi CT. (2013).Sensory evaluation, mineral, and amino acid composition of “ntubiri” and “ntiti-ikpa”, traditional foods of Ikwerre ethnic nationality in Nigeria. Pacific Journal of Science and Technology.2013; 14(1):295-300.
[36]. Ugbogu AE, Okezie E, Uche-Ikonne C, Duru M, Atasie OC. Toxicity evaluation of the aqueous stem extracts of Senna alata in Wistar rats. American Journal of Biomedical Research. 2016; 4(4): 80-86.
[37]. Dacie JV, Lewis SM. Practical haematology, Seventh edition edn. Edinburgh.: Churchill Livingstone, 1991.
[38]. Alexander RR, Griffths JM. Haematocrit in Basic Biochemical Methods, JohnWiley & Sons, New York, NY, USA, 2nd edition, 1993.
[39]. Hoff-Brand A.V, Pettit JE. Haematological Parameters in Essentials of Haematology, Blackwell Science, 4th edition, 2000.
[40]. Yakubu, MT, Akanji MA, Oladiji TA. Haematological evaluation in male albino rats following chronic administration of aqueous extract of Fadogia agrestis stem,” Pharmacognosy Magazine. 2007; vol. 3, article 34.
[41]. Adebayo AH, Abolaji AO, Opata TK, Adegbenro IK. Effects of ethanolic leaf extract of Chrysophyllum albidum G. on biochemical and haematological parameters of albino Wistar rats. African Journal of Biotechnology.2010; 9 (14): 2145– 2150.
[42]. Duru MKC, Amadi BA, Amadi CT, Lele KC, Anudike ,JC, Chima-Ezika OR, Osuocha K. Toxic effect of carica papaya bark on body weight, haematology, and some biochemical parameters. Biokemistri. 2012; 24(2):67-71.
[43]. Amadi BA, Agomuo EN, Duru MKC. Toxicological studies of Asmina triloba leaves on haematology, liver, kidney using rat model. International Science Research Journal. 2013; 4(2):11-17.
[44] Celik I, Suzek H. The hematological effects of methyl parathion in rats.Journal of Hazardous Materials.2008; 153 (3): 1117–1121.
[45] Adebayo, JO, Adesokan AA, Olatunji, LA, Buoro DA, Soladoye AO. Effect of ethanolic extract of Bougainvillea spectabilis leaves on haematological and serum lipid variables in ratsitm. Biokemistri. 2005; 17 (1): 45–50.
[46]. Hassan DI, Ogah, DM, Yusuf ND, Musa MM, Saidu GM. The effect of acute and chronic (short and long term) oral administrations of black pepper (Piper guineense) aqueous extract on the body weight and haematological values of albino- Wistar rat. Journal of Medicinal Plants Research. 2010; 4 (2):1122–1125.
[47]. Akubugwo EI, Duru MKC. Biochemical Implications of the consumption of water from Otamiri river, Owerri, Imo State, Nigeria. Journal of Emerging Trends in Engineering and Applied Sciences (JETEAS).2011; 2 (6): 934-937.
[48]. Olson H, Betton G, Robinson D, Thomas K, Monro A, Kolaja G, Lilly P, Sander J, Spies G, Bracken W, Dorato M, Deun KV, Smith P, Berger B, Heller A. Concordance of toxicity of pharmaceuticals in humans and in animals. Regul. Toxicol. Pharmacol. 2000; 32:56-67.
[49]. Duru MKC, Adindu EA, Odika PC, Amadi BA, Okazi CR. Consequences of long-term consumption of water from Nworie River (Owerri, Nigeria) on haematological, hepatic, and renal functions using rat model. Biokemistri.2012; 24 (1):52-57.
[50]. Aliyu R, Adebayo AH, Gatsing D, Garba IH. The effect of ethanolic leaf extract of Commiphora africana (Burseraceae) on rat liver and kidney functions. J. Pharmacol. Toxicol.2006; 2: 373-379.
[51]. Enemor VHA, Anosike JC, Nwoke BEB, Chikezie PC. Serum aminotransferase and bilirubin levels in Malaria patients. International Journal of Natural and Applied Sciences. 2005; 1(12): 85-89. [52]. Wurochekke AU, Anthony AE, Obidah W. Biochemical effects on liver and kidney of rats administered aqueous stem bark extract of Xemenia americana. African Journal of Biotechnology. 2008; 7(16):2777-2780.
How to Cite
Helen, I., Kalu, W., & Odika Prince, O. C. (2019). Effect of Vinca minor on biochemical parameters using Wistar albino rats. Journal of Scientific Agriculture, 3, 60–63. https://doi.org/10.25081/jsa.2019.v3.5487
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