Antihepatotoxic effect of Elephantopus scaber L. on carbon tetrachloride-induced hepatotoxicity in rats

Authors

  • Ganga Rao Batu A.U College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P, India-530003
  • Y Venkateswara Rao Department of Botany, A.U. College of Science and Technology, Andhra University, Visakhapatnam, A.P, India-530003
  • V S Praneeth Dasari Department of Botany, A.U. College of Science and Technology, Andhra University, Visakhapatnam, A.P, India-530003

Keywords:

Elephantopus scaber, Antihepatotoxic effect, Carbon tetrachloride (CCl4)

Abstract

Elephantopus scaber was used in folk medicine in several countries to treat different diseases. Liver diseases are major World wise health Problems. The Present aim of the study was evaluate The Antihepatotoxic effects of different fractions of Elephantopus scaber against Carbon tetrachloride (CCl4) induced hepatic damage in Rats. All the fractions were given orally in different doses (125mg/kg, 250mg/kg, 500mg/kg). The Antihepatotoxic effect was assessed by measuring serum parameters like  aspertate transaminase (AST), alanine transaminase (ALT), Alkaline Phospatase (ALP) and total bilurubin.  All the fractions of Elephantopus scaber showed Antihepatotoxic effect.The ethanol fraction was shows significant percentage protection than compared to other fractions. Therefore, our study supports the isolation and use of active constituents from Ethanol fraction of Elephantopus scaber in treating of liver disease.

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Author Biographies

Ganga Rao Batu, A.U College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P, India-530003

A.U College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P, India-530003

Y Venkateswara Rao, Department of Botany, A.U. College of Science and Technology, Andhra University, Visakhapatnam, A.P, India-530003

Department of Botany, A.U. College of Science and Technology, Andhra University, Visakhapatnam, A.P, India-530003

V S Praneeth Dasari, Department of Botany, A.U. College of Science and Technology, Andhra University, Visakhapatnam, A.P, India-530003

Department of Botany, A.U. College of Science and Technology, Andhra University, Visakhapatnam, A.P, India-530003

Published

19-05-2012

How to Cite

Batu, G. R., Venkateswara Rao, Y., & Praneeth Dasari, V. S. (2012). Antihepatotoxic effect of Elephantopus scaber L. on carbon tetrachloride-induced hepatotoxicity in rats. Recent Research in Science and Technology, 4(4). Retrieved from https://updatepublishing.com/journal/index.php/rrst/article/view/884

Issue

Volume 4, Issue 4 (2012)

Section

Articles