A Review on “Formulation, Development and Evaluation of Amisulpride Once Daily Tablet”

Authors

  • S. Shailesh1*, O.P. Mahatama2, N. Upadhyat1, H. Bishnoi1, S. Savita1

Abstract

The  objective  of  the  present  study  was  to  develop  once-daily  tablet  of  Amisulpride,  a  second generation  antipsychotic,  a  substituted  Benzamide.  The tablets were prepared by the wet granulation method.  Microcrystalline  Cellulose,  HydroxyPropylmethyl cellulose   (HPMC),  Talc,  Magnesium Stearate,  Iso  Propyl  alcohol, Xanthan Gum, Kollidone Cross Pobidone, Aerosil, Avesil  101, 112,  102, Sodium  B i-car bonate,  Poly  vinylpyrollidone  K-30,  Carbopol  with  varying  excipients  Six  bilayer  formulations AM1 –AM6 were  prepared by compressing  both Instant Release ( IR) and Sustained Release ( SR)  granules.  The granules were evaluated for bulk density, tapped density, compressibility, and Hausner ratio and moisture content. The tablets AM1– AM6 were evaluated. The granules showed satisfactory flow properties.  All  the  tablets  formulations  showed  acceptable  Pharmacotechnical  properties  and  complied within  specifications  for  tested  parameters.  The  results  of  dissolution  studies  indicated  that  the formulation    AM1 ,  AM2   and  AM3   the  release  retardant use in combination  of SR  part  &  IR  part, AM1 (80:20), AM2 (80:20)in combination of HPMC and poloxmer  188 and AM3   use is xanthane gum but process  not  fissile  and  dissolution  was  faster.  Formulation AM6 exhibited satisfactory drug release; amisulpride OD Bi- layer 400 mg tablets dissolved more than 90% in 24 hours.

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Published

02-06-2011

How to Cite

Upadhyat1, H. Bishnoi1, S. Savita1, S. S. O. M. N. (2011). A Review on “Formulation, Development and Evaluation of Amisulpride Once Daily Tablet”. Recent Research in Science and Technology, 3(7). Retrieved from https://updatepublishing.com/journal/index.php/rrst/article/view/738

Issue

Section

Pharmacy & Pharmacology