Quantitative Changes of Immune Complexes and Leukocyte Count Due to Periodontitis and their Effect on Diabetes Mellitus

Authors

  • Minakshi Sharma1, Veena Sharma2, M.K. Gupta3, Mukal Tailang4 and A.K. Pathak1*

Abstract

The formation of circulating immune complexes (CIC) is a normal human response but persistence elevated level of CIC is a feature of many diseased conditions. These immune complexes produced due to Periodontitis may give rise to a variety of systemic diseases such as type 2 diabetes mellitus (DA) and rheumatoid arthritis (RA). The aim of this study was to investigate the level of CIC in serum of patients with severe chronic Periodontitis and their effect on type 2 diabetes mellitus. Polyethylene glycol (6000) method was used to isolate immune complexes from sera. The concentration of immunoglobulins was determined by radial immunodiffusion plates.

The level of neutrophils(p<=0.001) and circulating immune complexes (IgG, IgM) in the sera of diabetic patients with Periodontitis were found to be significantly higher compared to control, Periodontitis and diabetic patients. This may suggest a bidirectional causal association between severe chronic Periodontitis and type 2 diabetes mellitus.

Downloads

Download data is not yet available.

Published

28-04-2011

How to Cite

Gupta3, Mukal Tailang4 and A.K. Pathak1*, M. S. V. S. M. (2011). Quantitative Changes of Immune Complexes and Leukocyte Count Due to Periodontitis and their Effect on Diabetes Mellitus. Recent Research in Science and Technology, 3(6). Retrieved from https://updatepublishing.com/journal/index.php/rrst/article/view/721

Issue

Volume 3, Issue 6 (2011)

Section

Health Sciences