Efficacy of Natural Inhibitors against PKC: An In silico approach to combat Cancer

Abstract

Protein Kinase C (PKC), a member of isozyme family plays an important role in cell growth regulation and differentiation and is being considered as a novel target of many anti-cancer drugs. In this study we have explored the affinity and interaction of some natural plant derived compounds against PKCα to find out some important active site amino acid residues that play an important role in the binding of inhibitors with the active site.