Antidiabetic activities of Cassia occidentalis

Abstract

The present investigation was carried out to evaluate the anti-diabetic activities of Cassia occidentalis (Seena, coffee weed), a well known medicinal plant commonly found in India and other tropical countries. Various medicinal properties have been attributed to this plant in the traditional system of Indian medicine. The aqueous and methanolic extracts of aerial parts, viz. leaves, stem and seeds of the plant, Cassia occidentalis possessed anti-hyperglycemic/ anti-diabetic activity against alloxan-induced animal model. All aqueous-treated rats showed no discernible behavioral changes up to 3000 mg/kg by oral route. No mortality was observed at this dose during 72 h observation period. Amongst all the extracts, potent anti-diabetic activity was observed in aqueous extracts of leaves of C. occidentalis followed by aqueous extracts of seeds and aqueous extracts of stem. In normal animals, significant (p<0.05) reduction in the blood glucose level was observed by the aqueous extracts as compared to the control and methanolic extracts. However, treatment of methanolic extracts of aerial parts of C. occidentalis could not bring back the sugar to normal levels. Acute and chronic treatment of the aqueous extract of aerial parts of C. occidentalis (3000 mg/kg) in alloxan-induced diabetic rats resulted in a significant (p<0.05) decrease in the elevated blood glucose levels as compared to the control, there was significant reduction in blood glucose level in the group treated with glibenclamide at 0.5 mg/kg. The results showed that blood glucose level gets decreased after varying the dose level. Thus the findings confirmed that level of blood glucose gets normal in dose-dependent manner.