Analysis of functional gene polymorphism in Glycyrrhiza uralensis

Authors

  • Ying Liu School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China
  • Wendong Li Department of Antibiotic, Beijing Institute for Drug Control, Beijing, China
  • Hao Wen School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China
  • Ya Gao School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China
  • Rui Yang School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China
  • Chunsheng Liu School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China

Keywords:

Glycyrrhiza uralensis, HMGR, SQS, gene polymorphism, glycyrrhizic acid

Abstract

Glycyrrhiza uralensis is widely used in Chinese herbal compound prescriptions. Itcontains various natural active components, among them glycyrrhizic acid is believed tobe the main effective constituent. The biosynthetic pathway of glycyrrhizic acid iscontrolled and regulated by many different enzymes. In our studies two functional genescoding 3-hydroxy-3-methylglutary CoA reductase (HMGR) and squalene synthase (SQS)were selected as target genes. Several kinds of polymorphism were discovered in thecDNA sequences and amino acid sequences of the two genes, and which inflected thelevel of glycyrrhizic acid in G. uralensis.

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Published

20-12-2013

How to Cite

Liu, Y., Li, W., Wen, H., Gao, Y., Yang, R., & Liu, C. (2013). Analysis of functional gene polymorphism in Glycyrrhiza uralensis. Research in Plant Biology, 3(6). Retrieved from https://updatepublishing.com/journal/index.php/ripb/article/view/2492

Issue

Vol. 3 No. 6 (2013)

Section

Articles