Phyllanthus niruri leaf extract and its mediated silver nanoparticles as anticancer agent against neuroblastoma cancer (SH-SY5Y) cell lines

Authors

  • Nur Shuhada Binti Zakaria Materials Technology Research Group (MaTRec), School of Chemical Sciences, Universiti Sains Malaysia, 11800 Gelugor, Penang, Malaysia
  • Boon-Keat Khor Centre for Drug Research, Universiti Sains Malaysia, Gelugor 11800, Penang, Malaysia
  • Nur Azimah Binti Rosdi Materials Technology Research Group (MaTRec), School of Chemical Sciences, Universiti Sains Malaysia, 11800 Gelugor, Penang, Malaysia
  • Nurul Ashikin Binti Abu Bakar Materials Technology Research Group (MaTRec), School of Chemical Sciences, Universiti Sains Malaysia, 11800 Gelugor, Penang, Malaysia
  • Nurul Farah Anis Binti Johari Materials Technology Research Group (MaTRec), School of Chemical Sciences, Universiti Sains Malaysia, 11800 Gelugor, Penang, Malaysia
  • Lifi Francis Materials Technology Research Group (MaTRec), School of Chemical Sciences, Universiti Sains Malaysia, 11800 Gelugor, Penang, Malaysia
  • Vikneswaran Murugaiyah Centre for Drug Research, Universiti Sains Malaysia, Gelugor 11800, Penang, Malaysia, Discipline of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor 11800, Penang, Malaysia
  • Thangamani Arumugam Department of Chemistry, Karpagam Academy of Higher Education, Coimbatore-641021, Tamil Nadu, India
  • Pandian Bothi Raja Materials Technology Research Group (MaTRec), School of Chemical Sciences, Universiti Sains Malaysia, 11800 Gelugor, Penang, Malaysia

DOI:

https://doi.org/10.25081/jp.2025.v17.9691

Keywords:

Phyllanthus niruri, Silver nanoparticles, Anticancer study, SH-SY5Y Neuroblastoma cell line

Abstract

Silver nanoparticles (AgNPs) have enormous potential in numerous medical uses, such as molecular imaging, drug delivery, and treatment of different diseases, including cancer. Among many AgNP syntheses, the eco-friendly production of AgNPs utilising plants has many advantages including, sustainable and inexpensive process. Further, it provides safer and more effective treatment of numerous diseases. In this research, Phyllanthus niruri (PN) leaf extract was utilised for the biological synthesis of AgNPs. UV-Vis spectroscopy, ATR-FTIR spectroscopy, FESEM-EDX, and TEM were applied to analyse the synthesised P. niruri - mediated silver nanoparticles (PN-AgNPs). The images from FESEM and TEM analysis show the AgNPs are in spherical shapes with surface sizes of 11 to 63 nm and 12 to 24 nm, respectively. The EDX spectrum indicates that the nanoparticles contain 88.46% silver. PN and PN-AgNPs were further investigated to see whether they have any anticancer properties against the SH-SY5Y neuroblastoma cell line. Both PN and PN-AgNPs were effective in killing cancer cells, but the results indicated that PN-AgNPs had higher cytotoxic effects than PN.

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Published

16-09-2025

How to Cite

Zakaria, N. S. B., Khor, B.-K., Rosdi, N. A. B., Bakar, N. A. B. A., Johari, N. F. A. B., Francis, L., Murugaiyah, V., Arumugam, T., & Raja, P. B. (2025). Phyllanthus niruri leaf extract and its mediated silver nanoparticles as anticancer agent against neuroblastoma cancer (SH-SY5Y) cell lines. Journal of Phytology, 17, 121–127. https://doi.org/10.25081/jp.2025.v17.9691

Issue

Volume 17, 2025

Section

Articles

Copyright (c) 2025 Nur Shuhada Binti Zakaria, Boon-Keat Khor, Nur Azimah Binti Rosdi, Nurul Ashikin Binti Abu Bakar, Nurul Farah Anis Binti Johari, Lifi Francis, Vikneswaran Murugaiyah, Thangamani Arumugam, Pandian Bothi Raja

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