Cytotoxicity effect and antioxidant potential of 5-Hydroxymethyl Furfural (5-HMF) analogues-An advance approach
DOI:
https://doi.org/10.25081/jp.2024.v16.8817Keywords:
Rivea hypocrateriformis, 5-HMF (5-hydroxymethyl-2-furfural), Quinoline, Antioxidant, AnticancerAbstract
Rivea hypocrateriformis (Desr.) Choisy is a profound medicinal belongs to the family Convolvulaceae. Natural products are considered as an alternative source for a positive approach to the drug design and drug discovery. R. hypocrateriformis is becoming the most important natural source to produce diverse phytometabolites with varying biochemical activities. Therefore, in the proposed study, we utilizing R. hypocrateriformis for isolating the 5-hydroxymethyl-2-furfural (5-HMF) and characterized it by different scientifically approved spectroscopic techniques namely 1HNMR, 13C NMR, FTIR and mass spectroscopy respectively. As a part of this study, the synthesis of chemical analogues has been achieved by coupling 5-HMF with quinoline derivatives and it was also studied for their antioxidant and anticancer potentials. The results demonstrated that amongst the test compounds, 3d and 3b have shown significant free radical scavenging assay followed by 3e and 3a with a maximum inhibitory effect, 76.69 %, 75.90 %, 67.60 % and 56.07 % respectively at 50 μg/mL. The anticancer activity studied through SRB assay showed that, compound 3a was effective at low concentration (10 μg/mL) against the Colo-205 cell line. This study demonstrated the applicability of R. hypocrateriformis against the cytotoxicity and antioxidant potential of 5-HMF. It can further be utilized by the researcher and pharmaceutical industry to design a potential drug candidate to treat cellular toxicity.
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Copyright (c) 2024 W. A. Al-Baadani, A. M. M. A. Al-Samman, R. Anantacharya, N. D. Satyanarayan, N. A. Siddique, A. Al. Maqati, Kahkashan
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