Acute and Sub-chronic Toxicity Study of Dregea volubilis Fruit in Mice

Authors

  • Moulisha Biswas1, Biswakanth Kar2, Tarun K Karan2, Sanjib Bhattacharya3, RB Suresh Kumar2, Ashoke K Ghosh4, Pallab K Haldar5*

Abstract

In present study, the safety profile of  Dregea volubilis fruits was evaluated by acute and sub-chronic toxicity study of the petroleum ether extract of D. volubilis fruit (PEDV) in Swiss albino mice. The oral median lethal dose (LD50) of PEDV was found to be 900 mg/kg body weight. For sub-chronic toxicity study PEDV was administered at the single daily dose of 200 mg/kg for 28 consecutive days and at 29th day the hematological, histological, serum and liver biochemical parameters were evaluated by sacrificing the animals. No mortality was observed during the course of whole study. No detectable alterations were found in hematological biochemical and histological parameters in PEDV treated group when compared to vehicle control group after 28 days. The results of present study therefore indicate that D. volubilis fruit is safe in Swiss mice demonstrating no noticeable toxicity.

Key words: Sub-chronic toxicity, Dregea volubilis, biochemical, LD50

Moulisha Biswas  et al.  Acute and Sub-chronic Toxicity Study of Dregea volubilis Fruit in Mice. J Phytol 2/8 (2010) 06-10.

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Author Biography

Moulisha Biswas1, Biswakanth Kar2, Tarun K Karan2, Sanjib Bhattacharya3, RB Suresh Kumar2, Ashoke K Ghosh4, Pallab K Haldar5*

1Bengal Institute of Pharmaceutical Sciences, Kalyani, Nadia 741235, India2Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India3Bengal School of Technology, Sugandha, Hooghly 712102, India4College of Pharmacy, Institute of Foreign Trade & Management, Moradabad 244001, India5Department of Pharmacology, Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim, 737136, India

Published

06-11-2010

How to Cite

K Karan2, Sanjib Bhattacharya3, RB Suresh Kumar2, Ashoke K Ghosh4, Pallab K Haldar5*, M. B. B. K. T. (2010). Acute and Sub-chronic Toxicity Study of Dregea volubilis Fruit in Mice. Journal of Phytology, 2(8). Retrieved from https://updatepublishing.com/journal/index.php/jp/article/view/2155

Issue

Section

Phytopharmacology