Anti -inflammatory and Acute Toxicity Effects of Pittosporum tetraspermum Wight and Arn. on Rats

Abstract

Abstract

The anti-inflammatory effect of Pittosporum tetraspermum was studied in carrageenan – induced oedema in albino rats. Among the plant parts tested the methanol extract of root bark and stem bark exhitbited significant (P<0.01) oedema suppressant activity. The potency of the extract of root bark was superior to the reference drug phenylbutazone. The result suggests that the bark of P. tetraspermum has potential anti-inflammatory activity that supports its use in folk-therapy for inflammatory disorders. The acute toxicity study proved that the crude extract of the bark was non-toxic up to 2g/kg per oral (p.o.).

Key words: Anti-inflammatory, Carrageenan, Acute-toxicity, Induced oedema

P.J. Rosakutty et al. Anti -inflammatory and Acute Toxicity Effects of Pittosporum tetraspermum Wight and Arn. on Rats. J Phytol 2/6 (2010) 14-20