Role of Vitamin A and Vitamin D in management of polycystic ovary syndrome

Authors

  • M. Vindhya Division of Molecular Biology, School of Life Sciences, JSS Academy of Higher Education and Research, SS Nagar, Mysuru-570015, Karnataka, India
  • S. Bhumika Division of Molecular Biology, School of Life Sciences, JSS Academy of Higher Education and Research, SS Nagar, Mysuru-570015, Karnataka, India
  • R. Mythreyi Division of Molecular Biology, School of Life Sciences, JSS Academy of Higher Education and Research, SS Nagar, Mysuru-570015, Karnataka, India
  • Karthikeyan Murugesan Department of Microbiology, Faculty of Medicine and Health Sciences, Quest International University, Malaysia
  • G. G. Swamy Department of Pathology, Faculty of Medicine and Health Sciences, Quest International University, Malaysia
  • Deepa Kandaswamy Department of Anatomy, Faculty of Medicine and Health Sciences, Quest International University, Perak, Malaysia
  • Jayabalan Valliyappan Department of Obstetrics and Gynaecology, Faculty of Medicine, Quest International University, Malaysia
  • Boojhana Elango Department of Microbiology, Muthayammal College of Arts and Science, Rasipuram, Namakkal-637408, Tamil Nadu, India
  • Kanthesh M. Basalingappa Division of Molecular Biology, School of Life Sciences, JSS Academy of Higher Education and Research, SS Nagar, Mysuru-570015, Karnataka, India
  • Maghimaa Mathanmohun Department of Microbiology, Muthayammal College of Arts and Science, Rasipuram, Namakkal-637408, Tamil Nadu, India

DOI:

https://doi.org/10.21839/jmhsr.2023.v6.8730

Keywords:

PCOS, Insulin resistance, Obesity, Vitamin A, Retinol-Binding protein 4 (RBP4), Vitamin D

Abstract

Polycystic ovarian syndrome (PCOS), a very common cause of infertility in reproductive age groups, has increased exponentially in the past few years registering 9% of cases annually worldwide. It is one of the most common syndromes which manifests hormone secretion and its activity. Insulin resistance, obesity, Vitamin and mineral deficiency, etc., are commonly associated with PCOS. Vitamin A is a lipid-soluble vitamin that is useful in antioxidant activity and steroid synthesis is known to prevent the occurrence of PCOS. Vitamin D, a steroid hormone originating from cholesterol is commonly known as “the sunshine vitamin,” is also one of the observed vitamin deficiencies in PCOS women. Supplementation of Vitamins in the diet is essential in the management of PCOS women. This review attempts to brief the role of Vitamin A and Vitamin D as an important agent to overcome the challenges of PCOS by reviewing the investigations of various authors about the potential role of supplementation of Vitamin A and Vitamin D in various model organisms and Randomised Clinical Trials (RCT’s).

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References

Abbott, D. H., Tarantal, A. F., & Dumesic, D. A. (2009). Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys. American Journal of Primatology, 71(9), 776-784. https://doi.org/10.1002/ajp.20679

Al-Daghri, N. M., Al-Attas, O. S., Alkharfy, K. M., Khan, N., Mohammed, A. K., Vinodson, B., Ansari, M. G., Alenad, A., & Alokail, M. S. (2014). Association of VDR-gene variants with factors related to the metabolic syndrome, type 2 diabetes and vitamin D deficiency. Gene, 542(2), 129-133. https://doi.org/10.1016/j.gene.2014.03.044

Antipatis, C., Ashworth, C. J., Riley, S. C., Hannah, L., Hoggard, N., & Lea, R. G. (2002). Vitamin A deficiency during rat pregnancy alters placental TNF-α signalling and apoptosis. American Journal of Reproductive Immunology, 47(3), 151-158. https://doi.org/10.1034/j.1600-0897.2002.1o049.x

Bizzaro, G., Antico, A., Fortunato, A., & Bizzaro, N. (2017). Vitamin D and autoimmune diseases: Is vitamin D receptor (VDR) polymorphism the culprit? Israel Medical Association Journal, 19(7), 438-443.

Chiang, C.-M., Ismaeel, A., Griffis, R. B., & Weems, S. (2017). Effects of vitamin D supplementation on muscle strength in athletes: A systematic review. Journal of Strength and Conditioning Research, 31(2), 566-574. https://doi.org/10.1519/JSC.0000000000001518

Clagett-Dame, M., & Knutson, D. (2011). Vitamin A in reproduction and development. Nutrients, 3(4), 385-428. https://doi.org/10.3390/nu3040385

Conaway, H. H., Henning, P., & Lerner, U. H. (2013). Vitamin A metabolism, action, and role in skeletal homeostasis. Endocrine Reviews, 34(6), 766-797. https://doi.org/10.1210/er.2012-1071

Dawson, M. I. (2000). The importance of vitamin A in nutrition. Current Pharmaceutical Design, 6(3), 311-325. https://doi.org/10.2174/1381612003401190

Dumont, A., Robin, G., Catteau-Jonard, S., & Dewailly, D. (2015). Role of anti-Müllerian hormone in pathophysiology, diagnosis and treatment of polycystic ovary syndrome: A review. Reproductive Biology and Endocrinology, 13, 137. https://doi.org/10.1186/s12958-015-0134-9

Edem, D. O. (2008). Vitamin A: A review. Asian Journal of Clinical Nutrition, 1(1), 65-82. https://doi.org/10.3923/ajcn.2009.65.82

Günalan, E., Yaba, A., & Yılmaz, B. (2018). The effect of nutrient supplementation in the management of polycystic ovary syndrome-associated metabolic dysfunctions: A critical review. Journal of the Turkish German Gynecological Association, 19, 220-232. https://doi.org/10.4274/jtgga.2018.0077

Hahn, S., Backhaus, M., Broecker-Preuss, M., Tan, S., Dietz, T., Kimmig, R., Schmidt, M., Mann, K., & Janssen, O. E. (2007). Retinol-binding protein 4 levels are elevated in polycystic ovary syndrome women with obesity and impaired glucose metabolism. European Journal of Endocrinology, 157(2), 201-207. https://doi.org/10.1530/EJE-07-0143

Hoeger, K. M., Dokras, A., & Piltonen, T. (2021). Update on PCOS: Consequences, challenges, and guiding treatment. The Journal of Clinical Endocrinology & Metabolism, 106(3), e1071-e1083. https://doi.org/10.1210/clinem/dgaa839

Humphrey, J. H., West Jr, K. P., & Sommer, A. (1992). Vitamin A deficiency and attributable mortality among under-5-year-olds. Bulletin of the World Health Organization, 70(2), 225-232.

Jiang, Y., Li, C., Chen, L., Wang, F., & Zhou, X. (2017). Potential role of retinoids in ovarian physiology and pathogenesis of polycystic ovary syndrome. Clinica Chimica Acta, 469, 87-93. https://doi.org/10.1016/j.cca.2017.03.025

Krul-Poel, Y. H. M., Snackey, C., Louwers, Y., Lips, P., Lambalk, C. B., Laven, J. S. E., & Simsek, S. (2013). The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: A systematic review. European Journal of Endocrinology, 169(6), 853-865. https://doi.org/10.1530/EJE-13-0617

Kulda, V. (2012). Vitamin D metabolism. Vnitrni Lekarstvi, 58(5), 400-404.

Lin, M.-W., & Wu, M.-H. (2015). The role of vitamin D in polycystic ovary syndrome. Indian Journal of Medical Research, 142(3), 238-240.

Lin, M.-W., Tsai, S.-J., Chou, P.-Y., Huang, M.-F., Sun, H. S., & Wu, M.-H. (2012). Vitamin D receptor 1a promotor −1521 G/C and −1012 A/G polymorphisms in polycystic ovary syndrome. Taiwanese Journal of Obstetrics and Gynecology, 51(4), 565-571. https://doi.org/10.1016/j.tjog.2012.09.011

Lujan, M. E., Chizen, D. R., & Pierson, R. A. (2008). Diagnostic criteria for polycystic ovary syndrome: Pitfalls and controversies. Journal of Obstetrics and Gynaecology Canada, 30(8), 671-679. https://doi.org/10.1016/S1701-2163(16)32915-2

Menichini, D., & Facchinetti, F. (2020). Effects of vitamin D supplementation in women with polycystic ovary syndrome: A review. Gynecological Endocrinology, 36(1), 1-5. https://doi.org/10.1080/09513590.2019.1625881

Miao, C.-Y., Fang, X.-J., Chen, Y., & Zhang, Q. (2020). Effect of vitamin D supplementation on polycystic ovary syndrome: A meta-analysis. Experimental and Therapeutic Medicine, 19(4), 2641-2649. https://doi.org/10.3892/etm.2020.8525

Moayeri, A., Rostamzadeh, A., Raoofi, A., Rezaie, M. J., Abasian, Z., & Ahmadi, R. (2020). Retinoic acid and fibroblast growth factor-2 play a key role on modulation of sex hormones and apoptosis in a mouse model of polycystic ovary syndrome induced by estradiol valerate. Taiwanese Journal of Obstetrics & Gynecology, 59(6), 882-890. https://doi.org/10.1016/j.tjog.2020.08.004

Mohammad, M. B., & Seghinsara, A. M. (2017). Polycystic ovary syndrome (PCOS), diagnostic criteria, and AMH. Asian Pacific Journal of Cancer Prevention, 18(1), 17-21. https://doi.org/10.22034/APJCP.2017.18.1.17

Mousa, A., Naderpoor, N., Teede, H. J., De Courten, M. P., Scragg, R., & De Courten, B. (2015). Vitamin D and cardiometabolic risk factors and diseases. Minerva Endocrinologica, 40(3), 213-230.

O’Byrne, S. M., & Blaner, W. S. (2013). Retinol and retinyl esters: Biochemistry and physiology. Journal of Lipid Research, 54(7), 1731-1743. https://doi.org/10.1194/jlr.R037648

Oberfield, S. E., Sopher, A. B., & Gerken, A. T. (2011). Approach to the girl with early onset of pubic hair. The Journal of Clinical Endocrinology and Metabolism, 96(6), 1610-1622. https://doi.org/10.1210/jc.2011-0225

Pu, Y., Wang, Z., Bian, Y., Zhang, F., Yang, P., Li, Y., Zhang, Y., Liu, Y., Fang, F., Cao, H., & Zhang, X. (2014). All-trans retinoic acid improves goat oocyte nuclear maturation and reduces apoptotic cumulus cells during in vitro maturation. Animal Science Journal, 85(9), 833-839. https://doi.org/10.1111/asj.12216

Tahaei, L. S., Eimani, H., Yazdi, P. E., Ebrahimi, B., & Fathi, R. (2011). Effects of retinoic acid on maturation of immature mouse oocytes in the presence and absence of a granulosa cell co-culture system. Journal of Assisted Reproduction and Genetics, 28, 553-558. https://doi.org/10.1007/s10815-011-9579-8

Tan, B. K., Chen, J., Lehnert, H., Kennedy, R., & Randeva, H. S. (2007). Raised serum, adipocyte, and adipose tissue retinol-binding protein 4 in overweight women with polycystic ovary syndrome: Effects of gonadal and adrenal steroids. The Journal of Clinical Endocrinology and Metabolism, 92(7), 2764-2772. https://doi.org/10.1210/jc.2007-0091

Thomson, R. L., Spedding, S., & Buckley, J. D. (2012). Vitamin D in the aetiology and management of polycystic ovary syndrome. Clinical Endocrinology, 77(3), 343-350. https://doi.org/10.1111/j.1365-2265.2012.04434.x

Trummer, C., Pilz, S., Schwetz, V., Obermayer-Pietsch, B., & Lerchbaum, E. (2018). Vitamin D, PCOS and androgens in men: A systematic review. Endocrine Connections, 7(3), R95-R113. https://doi.org/10.1530/EC-18-0009

Wickenheisser, J. K., Nelson-DeGrave, V. L., Hendricks, K. L., Legro, R. S., Strauss, J. F., & McAllister, J. M. (2005). Retinoids and retinol differentially regulate steroid biosynthesis in ovarian theca cells isolated from normal cycling women and women with polycystic ovary syndrome. The Journal of Clinical Endocrinology and Metabolism, 90(8), 4858-4865. https://doi.org/10.1210/jc.2005-0330

Wild, R. A., Rizzo, M., Clifton, S., & Carmina, E. (2011). Lipid levels in polycystic ovary syndrome: Systematic review and meta-analysis. Fertility and Sterility, 95(3), 1073-1079. https://doi.org/10.1016/j.fertnstert.2010.12.027

Wood, J. R., Dumesic, D. A., Abbott, D. H., & Strauss, J. F. (2007). Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis. Journal of Clinical Endocrinology and Metabolism, 92(2), 705-713. https://doi.org/10.1210/jc.2006-2123

Wood, J. R., Ho, C. K. M., Nelson-Degrave, V. L., McAllister, J. M., & Strauss, J. F. (2004) The molecular signature of polycystic ovary syndrome (PCOS) theca cells defined by gene expression profiling. Journal of Reproductive Immunology, 63(1), 51-60. https://doi.org/10.1016/j.jri.2004.01.010

Wood, J. R., Nelson, V. L., Ho, C., Jansen, E., Wang, C. Y., Urbanek, M., McAllister, J. M., Mosselman, S., & Strauss, J. F. (2003). The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis. Journal of Biological Chemistry, 278(29), 26380-26390. https://doi.org/10.1074/jbc.M300688200

Zhang, H. Y., Guo, C. X., Zhu, F. F., Qu, P. P., Lin, W. J., & Xiong, J. (2013). Clinical characteristics, metabolic features, and phenotype of Chinese women with polycystic ovary syndrome: A large-scale case-control study. Archives of Gynecology and Obstetrics, 287(3), 525-531. https://doi.org/10.1007/s00404-012-2568-z

Published

30-12-2023

How to Cite

Vindhya, M., S. Bhumika, R. Mythreyi, K. Murugesan, G. G. Swamy, D. Kandaswamy, J. Valliyappan, B. Elango, K. M. Basalingappa, and M. Mathanmohun. “Role of Vitamin A and Vitamin D in Management of Polycystic Ovary Syndrome”. Journal of Medicine and Health Sciences Research, vol. 6, Dec. 2023, pp. 7-11, doi:10.21839/jmhsr.2023.v6.8730.

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