Biological activities and Phytochemical analysis of Zanthoxylum armatum DC. leaves and bark extracts collected from Kumaun region, Uttarakhand, India

  • Anmol Singh Department of Chemistry, College of Basic Sciences and Humanities, G. B. Pant University of Agriculture and Technology, Pantnagar, U. S. Nagar- 263145, Uttarakhand, India
  • Diksha Palariya Department of Chemistry, College of Basic Sciences and Humanities, G. B. Pant University of Agriculture and Technology, Pantnagar, U. S. Nagar- 263145, Uttarakhand, India
  • Anamika Dhami Department of Chemistry, College of Basic Sciences and Humanities, G. B. Pant University of Agriculture and Technology, Pantnagar, U. S. Nagar- 263145, Uttarakhand, India
  • Om Prakash Department of Chemistry, College of Basic Sciences and Humanities, G. B. Pant University of Agriculture and Technology, Pantnagar, U. S. Nagar- 263145, Uttarakhand, India
  • Ravendra Kumar Department of Chemistry, College of Basic Sciences and Humanities, G. B. Pant University of Agriculture and Technology, Pantnagar, U. S. Nagar- 263145, Uttarakhand, India
  • Dharmendra Singh Rawat Department of Biological Sciences, College of Basic Sciences and Humanities, G. B. Pant University of Agriculture and Technology, Pantnagar, U. S. Nagar- 263145, Uttarakhand, India
  • Anil Kumar Pant Department of Chemistry, College of Basic Sciences and Humanities, G. B. Pant University of Agriculture and Technology, Pantnagar, U. S. Nagar- 263145, Uttarakhand, India

Abstract

The methanolic and chloroform extracts of leaves and bark of Zanthoxylum armatum DC. were evaluated for their phytochemical analysis and biological activities. In phytochemical analysis, fargsin was identified as major constituent in leaves methanolic and leaves chloroform extracts. t-butylamine and benzoxazole, 2-(isobutylamino) were identified as the major constituents in bark methanolic and bark chloroform extracts respectively. Both the extracts exhibited moderate antioxidant activity with IC50 values ranging from 19.42±0.07 to78.01±0.31 µg. These extracts also possess moderate anti-inflammatory activity with IB50 values ranging from 28.53 ± 0.06 to 89.80 ± 0.05 µg. Moderate anti-bacterial activity against E. coli and S. aureus has also been observed in both the extracts. The total flavonoids, orthodihydric phenols and phenolic contents were also quantified in the extracts. Based on these observations, it can be concluded that Zanthoxylum armatum DC. may be used as herbal antioxidant, food preservative, natural anti-inflammatory drug and natural bactericidal, besides generation of data base for judicious exploitation in future.

Keywords: Zanthoxylum armatum; antioxidant activity; anti-inflammatory activity; anti-bacterial activity; total phenolics; total flavonoids; orthodihydric phenols

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How to Cite
Singh, A., D. Palariya, A. Dhami, O. Prakash, R. Kumar, D. Rawat, and A. Pant. “Biological Activities and Phytochemical Analysis of Zanthoxylum Armatum DC. Leaves and Bark Extracts Collected from Kumaun Region, Uttarakhand, India”. Journal of Medicinal Herbs and Ethnomedicine, Vol. 6,  , pp. 1-10, doi:https://doi.org/10.25081/jmhe.2020.v6.5754.
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Research Article