Antimicrobial and antipyretic activities of aqueous leaf extract of Spondias mombin Linn. (Anarcadiaceae)

  • E.O. Agbaje Department of Pharmacology, Therapeutics & Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Pmb 12003, Lagos, Nigeria
  • A.I. Ismail Department of Pharmacology, Therapeutics & Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Pmb 12003, Lagos, Nigeria
  • O.J. Oguntokun Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Jos, Jos-Plateau State, Nigeria

Abstract

Spondias mombin (Linn.) (Anacardiaceae) is an herbaceous plant widely used in Traditional African medicine (TAM) for the treatment of diverse ailments including infections and febrile conditions. This study was conducted to investigate the antimicrobial and antipyretic properties of the aqueous leaf extract of S. mombin. The sensitivity test (using zones of inhibition), minimum inhibitory concentration and minimum bactericidal concentration tests were used to investigate its antimicrobial properties, while the 2,4-dinitrophenol (DNP)- and yeast-induced hyperthermia tests were used to investigate antipyretic activity in rodents. S. mombin (50, 100 and 200 mg kg-1, p.o) produced significant (p<0.05) antimicrobial activity in the sensitivity test. The effects of 50, 100 and 200 mg/ml S. mombin were generally comparable to those of ciprofloxacin. Also, S. mombin produced significant (p<0.05) reduction of elevated temperature in the 2,4-DNP and yeast-induced hyperthermia models with peak effects of anti-pyrexia produced at 200 mg kg-1 for 2,4-DNP induced hyperthermia and 100 mg kg-1 for the yeast-induced. The effect at these doses was comparable to that of paracetamol, being the positive control in the two models. The results obtained in this study demonstrated that the aqueous leaf extract of Spondias mombin possesses antibacterial and antipyretic properties.

Keywords: antimicrobial, antipyretic, Spondias mombin, extract

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How to Cite
Agbaje, E., A. Ismail, and O. Oguntokun. “Antimicrobial and Antipyretic Activities of Aqueous Leaf Extract of Spondias Mombin Linn. (Anarcadiaceae)”. Journal of Medicinal Herbs and Ethnomedicine, Vol. 6, &nbsp;, pp. 21-29, doi:https://doi.org/10.25081/jmhe.2020.v6.5558.
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Research Article