Chemical Composition, Anti-inflammatory, Analgesic, Antipyretic, Myorelaxant, Antibacterial and Antifungal activity of Rabdosia rugosus Wall. (Syn. Plectranthus rugosus Wall.)

  • Prakash Singh, Ravendra Kumar
  • Om Prakash, Anil Kumar Pant Department of Chemistry, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar, U.S. Nagar, 263145 Uttarakhand, India
  • Mahesh Kumar Department of Veterinary Epidemiology and Preventive Medicine, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar, U.S. Nagar, 263145 Uttarakhand, India
  • Valary A. Isidorov, Lech Szczepaniak Institute of Chemistry, Division of Environmental Chemistry, UL, Bialystok University, Hurtowa 1,15-399 Bialystok, Poland

Abstract

For the present investigation Rabdosia rugosus Wall. Syn. Plectranthus rugosus Wall.  was collected from Pancheshwar, Uttarakhand on the way to Badrinath. The GC and GC-MS analysis, revealed the presence of more than forty compounds out of which 35 compounds were identified amounting to 97.3% of the total oil. The essential oil of R. rugosus was rich in sesquiterpinoids (~90%) and was poor in monoterpenoids (8.1%). α-bisabolol (41.9%) was the major constituent of the oil and the other identified major compounds were germacrene-D (9.7%), β-caryophyllene (7.6%), dehydroabietane (5.2%), ar-curcumene (5.0), trans-ferruginol (3.3%) α-cadinol (3.2%), τ-muurolol (2.3%),   p-Cymene (3.2%) and  γ-terpinene (2.0%). The  essential  oil  of  Rabdosia rugosus showed insignificant  anti-inflammatory  and  analgesic  activity  but  shows  significant  antipyretic,   myorelaxant and  antimicrobial activity.

Keywords: Rabdosia rugosus; ?-bisabolol; anti-inflammatory activity; myorelaxant activity; antimicrobial activity

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References

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Ravendra Kumar, P. S., O. P. Anil Kumar Pant, M. Kumar, and V. A. I. Lech Szczepaniak. “Chemical Composition, Anti-Inflammatory, Analgesic, Antipyretic, Myorelaxant, Antibacterial and Antifungal Activity of Rabdosia Rugosus Wall. (Syn. Plectranthus Rugosus Wall.)”. Journal of Medicinal Herbs and Ethnomedicine, Vol. 5,  , pp. 08-15, doi:https://doi.org/10.25081/jmhe.2019.v5.3831.
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Research Article