Role of Flavonoids in Combating Hyperuricemia

Authors

  • Basavaraj Gorrjanal Division of Molecular Biology, School of Life Sciences- Mysuru, JSS Academy of Higher Education and Research, Mysuru-570015, Karnataka, India
  • B. M. Monika Division of Molecular Biology, School of Life Sciences- Mysuru, JSS Academy of Higher Education and Research, Mysuru-570015, Karnataka, India
  • R. Mythreyi Division of Molecular Biology, School of Life Sciences- Mysuru, JSS Academy of Higher Education and Research, Mysuru-570015, Karnataka, India
  • Karthikeyan Muthusamy Department of Bioinformatics, Science Campus, Alagappa University, Karaikudi-630003, Tamil Nadu, India
  • Karthikeyan Murugesan Department of Microbiology, Faculty of Medicine and Health Sciences, Quest International University, Malaysia
  • Anjuna Radhakrishnan Department of Microbiology, Faculty of Medicine and Health Sciences, Quest International University, Malaysia
  • S. Jagannathan Pasteur Institute of India, Coonoor-643103, The Nilgiris, Tamil Nadu, India
  • Boojhana Elango Department of Microbiology, Muthayammal College of Arts and Science, Rasipuram, Namakkal-637408, Tamil Nadu, India
  • Kanthesh M. Basalingappa Division of Molecular Biology, School of Life Sciences- Mysuru, JSS Academy of Higher Education and Research, Mysuru-570015, Karnataka, India
  • Maghimaa Mathanmohun Department of Microbiology, Muthayammal College of Arts and Science, Rasipuram, Namakkal-637408, Tamil Nadu, India

DOI:

https://doi.org/10.25081/imrj.2023.v13.8731

Keywords:

Hyperuricemia, Flavonoids, Xanthine oxidase, Hyperuricemic mice, Urate transporters

Abstract

Individuals tend to have an increased blood uric acid level at a younger age due to their dietary choices and lifestyle, which can lead to major health concerns such as hyperuricemia, gout, cardiovascular disease, nephropathy, and inflammation. Flavonoids have been proven to have strong inhibitory action against xanthine oxidase and be able to lower serum uric acid levels, levels of adenosine deaminase, gene expressions of renal glucose transporter type 9 (mGLUT9) and uric acid transporter 1 (mURAT1), along with increased expression of organic anion transporters (mOAT1 and mOAT3) and organic cation transporters (mOCT1 and mOCT2). Furthermore, flavonoids enhanced renal function and antioxidant activity in hyperuricemic rats. In hyperuricemic mice, genistein reduced renal fibrosis by inhibiting the JAK2/STAT3 and Wnt/β-catenin signaling pathways. Overall, this review reveals that the flavonoids have substantial anti-hyperuricemia and associated disease potential and may be utilized as natural supplements for the treatment of Uric acid-related illnesses.

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Published

30-12-2023

How to Cite

Gorrjanal, B., B. M. Monika, R. Mythreyi, K. Muthusamy, K. Murugesan, A. Radhakrishnan, S. Jagannathan, B. Elango, K. M. Basalingappa, and M. Mathanmohun. “Role of Flavonoids in Combating Hyperuricemia”. International Multidisciplinary Research Journal, vol. 13, Dec. 2023, pp. 25-31, doi:10.25081/imrj.2023.v13.8731.

Issue

Volume 13, 2023

Section

Articles

Copyright (c) 2023 Basavaraj Gorrjanal, B. M. Monika, R. Mythreyi, Karthikeyan Muthusamy, Karthikeyan Murugesan, Anjuna Radhakrishnan, S. Jagannathan, Boojhana Elango, Kanthesh M. Basalingappa, Maghimaa Mathanmohun

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