Comparative study of acute and chronic exposure of chloramphenicol on total lipid contents in different tissues of model animals, Lamellidens corrianus (Lea) and Parreysia cylindrica (Annandale and Prashad)

Abstract

Upon lethal treatment of one of the broad spectrum antibiotics, chloramphenicol against the increase lipid contents in all tested tissues, there was increase in the total lipids content over different durations. Exposure to sub-lethal concentration, the amount of total lipids content, increased.   Changes in the lipid metabolism due to lethal concentration of chloramphenicol exposure could reveal the positive impact on the metabolic activities, which would result in increase in lipid contents in both the selected models, Lamellidens corrianus and   Parreysia cylindrica.   The acute dose of chloramphenicol given to Lamellidens corrianus was 470.37PPM and to Parreysia cylindrica was 369.09PPM.  The sub lethal concentrations used were 94.07 PPM in case of L. corrianus and 73.81 PPM in case of P. cylindrica up to 21 days.  The total lipid content was estimated after 24 and 96 hours of acute treatment and after 7, 14 and 21 days of chronic treatment in the mantle, gills, foot, ovary, testis, digestive glands and whole body of the bivalves. Upon acute and chronic exposure of chloramphenicol, L. corrianus and P. cylindrica showed increase in total lipid contents.  There was overall increase in lipid contents in different tissues of both the species of bivalves.  Ovary and testis showed marked increase against chloramphenicol treatment.  Maximum increase in lipid contents was found in ovary after chronic treatment and least by mantle at the same exposure.  The increase in lipid contents may be due to the lipogenesis occurring in the ovary for production and emission of gametes.