In-vitro antiulcer activities of petal extract of Crocus sativus var. cashmerianus

  • Vijender Kumar University Institute of Pharmaceutical Sciences & Research, BFUHS, Faridkot-151203, Punjab, India
  • Poonam Verma Lala Lajpat Rai College of Pharmacy, Near P. S. Sadar, Moga-142001, Punjab, India
  • Amarjit Kaur Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga-142001, Punjab, India
  • Baljinder Singh Lala Lajpat Rai College of Pharmacy, Near P. S. Sadar, Moga-142001, Punjab, India

Abstract

Medicinal plants have been known for millennia as a rich source of traditional therapeutic agents for the prevention of diseases and ailments. The aim of the present study was performed to evaluate the antiulcer activities of hydro-alcoholic extracts of petals of Crocus sativus var. Cashmerianus by in-vitro methods viz. acid neutralizing capacity and H+/K+ - ATPase inhibition activity. In acid neutralizing capacity method, the petals extract significantly reduced acidity to 6.10 at a concentration of 1000 mg/ml as compared to 11.90 with standard 500 mg/ml of Aluminium hydroxide + Magnesium hydroxide combination. However, H+/K+ - ATPase inhibition activity method, petals extract showed maximum percentage inhibition of 70.31 % at the concentration 400µg/ml as compared to 73.82 % with a similar dose of standard Omeprazole. The IC 50 value of petals extract of C. sativus var. cashmerianus is shown 100 µg/ml in comparison with standard omeprazole of 82.5 µg/ml. The study reveals that the petals extract of C. sativus var. cashmerianus may contain compounds possessing acid neutralize and enzyme inhibition activities, thus it can be used as an alternative medicine for gastrointestinal disorders.

Keywords: C. sativus, Acid Neutralizing capacity, H /K - ATPase inhibition activity, Omeprazole

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