TY - JOUR AU - T. Lazar Mathew2, R. Regina Mary1, K.M.Gothandam2*, PY - 2010/08/23 Y2 - 2024/03/29 TI - Increased Frequency of Down Syndrome in Young Mothers of Rural Population JF - Journal of Ecobiotechnology JA - JEBT VL - 2 IS - 3 SE - REGULAR ISSUE ARTICLES DO - UR - https://updatepublishing.com/journal/index.php/jebt/article/view/38 SP - AB - <p><span style="font-size: 10pt; line-height: 110%; font-family: ">Studies were conducted in 222 children clinically diagnosed with Down syndrome (properly diagnosed on the basis of symptoms by Dr. Chandraleka, Pediatrician) to understand the frequency and type distribution of such cases; and to determine the origin of extrachromosome in the 21<sup>st</sup> pair. Clinical diagnosis was confirmed with karyotyping. Results have shown that nondisjunction or pure trisomy 21 appears to be the main cytogenetic cause; with a percentage frequency of 96.4%; comprising of 114 boys (53.3%) and 108 girls (46.7%). Also the cytological and molecular analysis result revealed that Down syndrome was increased in the young Indian mothers especially in the rural areas.</span></p><p style="text-align: center;"><span style="font-size: 10pt; line-height: 110%; font-family: ">--------------------------------------------------------------------------------------------------------</span></p><span style="font-size: 10pt; line-height: 110%; font-family: "><span style="font-size: 10pt; font-family: "><p class="MsoNormal" style="margin: 0in 0in 0pt; text-indent: 0in; line-height: normal; text-align: left;" align="left"><em><span style="font-size: 10pt; font-family: ";Garamond";,";serif";;">1Department of Advanced Zoology </span></em><em style="mso-bidi-font-style: normal;"><span style="font-size: 10pt; font-family: ";Garamond";,";serif";;">&</span><span style="font-size: small; font-family: Times New Roman;"> </span></em><em><span style="font-size: 10pt; font-family: ";Garamond";,";serif";;">Biotechnology, Auxillium College, Vellore</span></em></p><p class="MsoNormal" style="margin: 0in 0in 0pt; text-indent: 0in; line-height: normal; text-align: left;" align="left"><em><span style="font-size: 10pt; font-family: ";Garamond";,";serif";;">2School of Bio Sciences & Technology, VIT University, Vellore – 632014</span></em></p><p class="MsoEndnoteText" style="margin: 0in 0in 0pt 0.25in; text-indent: 0in;"><em><span style="font-size: 10pt; line-height: 110%; font-family: ";Garamond";,";serif";; mso-fareast-font-family: SimSun; mso-fareast-language: ZH-CN; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: EN-US; mso-bidi-language: AR-SA;">*Corresponding author, Email: <a href="mailto:gothandam@yahoo.com">gothandam@yahoo.com</a> </span></em></p><p class="MsoEndnoteText" style="margin: 0in 0in 0pt 0.25in; text-indent: 0in;"><em></em></p><p class="MsoEndnoteText" style="margin: 0in 0in 0pt 0.25in; text-indent: 0in;"><strong><span style="text-decoration: underline;"><span style="font-size: 10pt; font-family: ">Please Cite This Article As:</span></span></strong><span style="text-decoration: underline;"><span style="font-size: 10pt; font-family: "> </span></span></p><p class="MsoEndnoteText" style="margin: 0in 0in 0pt 0.25in; text-indent: 0in;"><span style="font-size: 10pt; font-family: "> </span></p><p style="text-align: left;"><span style="font-size: 9pt; line-height: 110%; font-family: ">R. Regina Mary, K.M. Gothandam, T. Lazar Mathew. 2010. Increased Frequency of Down Syndrome in Young Mothers of Rural Population. Journal of Ecobiotechnology 2/3: 40-44.</span></p></span></span> ER -