@article{Menon2_2010, title={Supplementation of (Trigonella foenum-graecum L.) Fenugreek Leaves Stimulates the Insulin Action in Streptozotocin- Induced Diabetic Rats}, volume={2}, url={https://updatepublishing.com/journal/index.php/jebt/article/view/36}, abstractNote={<p><span style="font-size: 10pt; line-height: 110%; font-family: ";Garamond";,";serif";; mso-fareast-font-family: SimSun; mso-fareast-language: ZH-CN; mso-bidi-font-family: ’Times New Roman’; mso-ansi-language: EN-US; mso-bidi-language: AR-SA;"><em>Trigonella foenum-graecum</em></span><span style="font-size: 10pt; line-height: 110%; font-family: ";Garamond";,";serif";; mso-fareast-font-family: SimSun; mso-fareast-language: ZH-CN; mso-bidi-font-family: ’Times New Roman’; mso-ansi-language: EN-US; mso-bidi-language: AR-SA;"> (Fenugreek) leaves exhibit antidiabetic and antioxidant properties. The present study was designed to elucidate the insulin stimulatory effect on supplementation of fenugreek leaves in streptozotocin-induced diabetes in rats. Supplementation of fenugreek leaves mixed with diet at doses of 0.5g and 1.0g/kg of body weight twice daily to diabetic rats for a period of 45days resulted in change in bodyweight, increase in weight of pancreas, enhances the insulin levels and a significant decrease in fasting blood glucose levels. Histopathological observations showed marked changes of the pancreas in treatment with the fenugreek leaves improved the functional state of the pancreatic β-cells and partially retained the damage caused by streptozotocin to the pancreatic islets. These findings of our study clearly indicate the insulin stimulatory effect of fenugreek leaves. The effect observed with the fenugreek leaves was better than that of glibenclamide (600 µg/kg bodyweight). </span></p><p style="text-align: center;"><span style="font-size: 10pt; line-height: 110%; font-family: ";Garamond";,";serif";; mso-fareast-font-family: SimSun; mso-fareast-language: ZH-CN; mso-bidi-font-family: ’Times New Roman’; mso-ansi-language: EN-US; mso-bidi-language: AR-SA;">----------------------------------------------------------------------------------</span></p><span style="font-size: 10pt; line-height: 110%; font-family: ";Garamond";,";serif";; mso-fareast-font-family: SimSun; mso-fareast-language: ZH-CN; mso-bidi-font-family: ’Times New Roman’; mso-ansi-language: EN-US; mso-bidi-language: AR-SA;"><p class="MsoNormal" style="margin: 0in 0in 0pt; text-indent: 0in; line-height: normal; text-align: left;" align="left"><em><sup><span style="font-size: 10pt; font-family: ";Garamond";,";serif";;">1</span></sup></em><em><span style="font-size: 10pt; font-family: ";Garamond";,";serif";;">Reader, Department of Biochemistry, Sathyabama University Dental College and Hospital, Chennai, Tamil Nadu, India</span></em></p><p class="MsoNormal" style="margin: 0in 0in 0pt; text-indent: 0in; line-height: normal; text-align: left;" align="left"><em><sup><span style="font-size: 10pt; font-family: ";Garamond";,";serif";;">2</span></sup></em><em><span style="font-size: 10pt; font-family: ";Garamond";,";serif";;">Director of Research, Ex-Dean of Science, Department of Biochemistry and Biotechnology, Annamalai University, Chidambaram</span></em></p><p class="MsoNormal" style="margin: 6pt 0in 0pt; text-indent: 0in; line-height: normal; text-align: left;" align="left"><em><span style="font-size: 10pt; font-family: ";Garamond";,";serif";;">*Corresponding author, Email: <a href="mailto:annidabalakrishnan@yahoo.co.in"><span style="color: windowtext; text-decoration: none; text-underline: none;">annidabalakrishnan@yahoo.co.in</span></a>, Ph: +91-44- 24503064, Mob: +91-9244488676</span></em></p><p style="text-align: left;">Cite This Article As:</p><p class="Abstract" style="margin: 0in -1.8pt 0pt 0in; text-align: left; tab-stops: center 2.75in right 5.5in left 472.5pt;" align="left"><span style="font-size: 10pt; font-family: ";Garamond";,";serif";;">Annida Balakrishnan and Venugopal. P. Menon. 2010. </span>Supplementation of (Trigonella foenum-graecum L.) Fenugreek Leaves Stimulates the Insulin Action in Streptozotocin- Induced Diabetic Rats. J. Ecobiotechnol. 2(3): 26-32.</p></span>}, number={3}, journal={Journal of Ecobiotechnology}, author={Menon2, Annida Balakrishnan1* and Venugopal. P.}, year={2010}, month={Jul.} }